In silico and in vivo Biological Evaluation of Chenopodium quinoa on Scopolamine Induced Memory Impairment in Mice

Aims: The present research is focused on screening in vivo and insilico anti- amnesic activity of the ethanolic extract seeds Chenopodium quinoa. To establish exact mechanism action, phytochemical constituents were subjected to silico studies using schrodinger pass software.
 Methodology: powdered material quinoa dried extracted with ethanol by soxhlation technique. In evaluation was carried Transfer latency Elevated plus maze, Novel object recognition test Passive avoidance time cook’s pole climbing apparatus. major phytoconstituents molecular docking PDB ID: 1EVE, 6N33, 2FV5 6W2X. Prediction for biological activities, adverse effects, direct possible targets PASS (Predictions spectra substances) online Results: administered at doses (200 mg/kg 400 mg/kg) showed significant activity. prolongation transfer (secs) elevated plus-maze as an indicator impairment learning memory. objective memorizing familiar that novel taken each animal recognize compare noted. results revealed Quercetin, Beta sitosterol, Kaempferol, Dimethyl sulphide, Myristic acid, Palmitic Stigmasterol, Lenolenic Pentadecanoic Tocopherols, Arachidonic acid standard Donepezil have got highest glide scores against ADME higher oral bioavailability. prediction Conclusion: From it evident possessed